Activation and Expansion, Designed to Translate
Early activation decisions impact cell quality, process complexity, and costs.
CellPilot™ products pair enhanced expansion performance with practical workflow improvements that reduce hands‑on time, simplify operations, and support translation beyond early research for T Cell, CAR, NK, TIL, iPSC and more.
Designed for Simplicity. And Scale Up.
CellPilot offers a biocompatible, bead-free activation platform that drops into standard workflows.
Tunable Activation
Fewer Steps, Less Rework
Built to
Translate
Optimized configuration of signaling molecules allows teams to direct toward the phenotype they need: effector vs. memory or CD4:CD8 composition.
Choice of signals and their configuration provide flexibility to integrate easily into current workflows. Our products can be integrated into current cell types (i.e., K562) or used as an alternative expansion reagent.
Reagents designed to balance choice with consistency enable early activation decisions during development that can offer quickly adapted, acceptable, incremental changes as needed in manufacturing.
Options to Support Enhanced Activation
CellPilot™ EXPLORER
Your Signals on Your Cells, in Hours
Design-driven modification of your presenting cells.
Drop-in sbPCI structures: no genetic modifications, no workflow overhaul.
Compatible
Anchor inserts into any lipid bilayer
Easy to Integrate
Cells modified in <4 hours
Flexible
Quantity and signal ratio adjustable to application
PROGRAMMING DECISIONS
Presenting Cell
Distance & Position
Stoichiometry & Density
COMPATIBLE SIGNALS
Anti-bodies & Antigens
Cytokines & Ligands
Fluorescent Labels
CellPilot™ EXPANDERS
High Performance T-Cell & CAR-T Expansion
Biocompatible expansion, simpler workflows.
Anchored-sbPCI configurations: replaces bead- and nanoparticle-based reagents
Directed
Designed to promote expansion or persistence
Biocompatible
No removal & isolation free
Efficient
Simplified workflow with lower COGs & touchpoints
T CELL EXPAND & CYTOEXPAND
CD3/CD28
CD3/CD28 + IL2
CD3/CD28 + IL2/15
CD3/CD28/CD137
CD3/CD28/CD137 + IL2
CD3/CD28/CD137 + IL2/15
CAR-T EXPAND & CYTOEXPAND
CD19/CD28/CD137
CD19/CD28/CD137 + IL2/15
CD3/CD28/CD137 + IL7/15
CellPilot™ CUSTOM
Phenotype-Directed Formulations
Tailored cell interactions, delivered in 2-6 weeks.
Library-based high-throughput screening that supports diverse cell types and applications; integrates with existing products (Stimulus Inside)
IDEAL FOR: Therapeutic and instrument developers looking for tailored activation options integrated into their unique workflows.
Why Teams Choose CellPilot™
Reconfigure signaling without rebuilding cell lines. Modular surface assembly lets teams rapidly test costimulatory components and signal ratios without engineering cell lines.
Drop into your existing workflow. Bead-free and self-terminating design eliminates upfront isolation, backend bead removal, and need for specialized equipment.
Make phenotype-informed decisions earlier. Tune key performance levers during activation, so program-defining choices happen early.
Use less reagent to do more. Integrated cytokine delivery reduces required volumes and hands-on additions while supporting expansion performance.
Carry your conditions from discovery to manufacturing. Activation conditions established at the bench translate forward into a run-ready process with fewer re-optimizations
The Technology Behind CellPilot™
All CellPilot products are built on sbPCI™ (programmable cell‑surface interface) technology, which controls how activation and co‑stimulatory signals are presented at the cell surface.
sbPCI enables defined, localized signal presentation without genetic modification, creating the foundation for both workflow‑ready solutions and rapid, screening‑driven configuration for custom applications. The same underlying technology supports bead‑free formats, signaling molecule flexibility, and fast iteration from discovery into process development.
Replace Fixed Activation with Flexibility
