sbPCI-NK Expander enables feeder-free NK expansion from unfractionated PBMCs without NK-specific media. sbPCI-IL21 activates STAT3 equivalently to soluble delivery yet produces distinct receptor and cytotoxic profiles, indicating that immune synapse architecture, not signal strength alone, is a tunable lever for NK manufacturing.
Authors: Ayomide Oloyede, Javi Bravo-Alegria, Andres Campos, Siddharth Subham, Jinchun Wang, Colleen M O’Connor, Andries Zijlstra
StimulusBio at the American Society of Gene & Cell Therapy on May 2026
in Boston, MA
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